A RARE CAUSE OF AN OVARIAN MASS

John Bashford, H Simpson

Abstract


Multiple Endocrine Neoplasia Type IIB (MEN-IIB) is a syndrome characterised by the presence of medullary thyroid carcinoma (MTC), phaeochromcytomas, neuromas and a marfanoid habitus.  The MTC seen in MEN-IIB patients is often more aggressive, and carries a poorer prognosis, than its MEN-IIA or sporadic counterparts.  The most common mutation in MEN-IIB patients is a RETMet918Thr substitution, causing overactivity of the oncogene RET tyrosine kinase.  We present a rare case of ovarian metastatic spread of MTC in a patient with MEN-IIB.


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