‘STEP VERTEBRAE’, ‘FISH MOUTH VERTEBRAE’ OR ‘H VERTEBRAE’ IN SICKLE CELL DISEASE

Charity Huang, T Zehrer, L Mueller, Colin Michie

Abstract


Sickle cell disease is associated with damage to bony tissues, particularly in adults (1-3). The severity of the sickling condition, as well as genetic determinants such as that for annexin and steroid hormones such as vitamin D are being investigated epidemiologically to ascertain their relative significance. Most bony changes are not visible on clinical examination. We present an image from a teenager who presented with back pain and radiographic changes in his vertebrae.

Keywords


Vertebra, Sickle cell, Fish-mouth, Step vertebra, H-shaped vertebra, bone Infarction

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References


Da Silva Jr GB, Daher Ede F, da Rocha FA. Osteoarticular involvement in sickle cell disease. Revista Brasileira de Hematologia e Hemoterapia. 2012; 34(2): 156-64

Fung EB, Harmatz PR, Milet M, Coates TD, Thompson AA, Ranalli M, Mignaca R, Scher C, Giardina P, Robertson S, Neumayr L, Vichinsky EP; Multi-Center Iron Overload Study Group. Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia. Bone. 2008;43(1):162-

Lal A, Fung EB, Pakbaz Z, Hackney-Stephens E, Vichinsky EP. Bone mineral density in children with sickle cell anemia. Pediatr Blood Cancer. 2006;47(7):901-6.

Ntagiopoulos PG, Moutzouris DA, ManetasS. The “fish-vertebra” sign. Emergency Medicine Journal. 2007; 24(9): 674-675.

Reynolds J. A re-evaluation of the “fish vertebra” sign in sickle cell hemoglobinopathy. American Journal of Roentgenology. 1966; 97: 693-707.

Serarslan Y, Kalaci A, Ozkan C, Doğramaci Y, Cokluk C, Yanat AN. Morphometry of the thoracolumbar vertebrae in sickle cell disease. J Clin Neurosci. 2010;17(2):182-6.

Adewoye AH, Chen TC, Ma Q, McMahon L, Mathieu J, Malabanan A, Steinberg MH, Holick MF. Sickle cell bone disease: response to vitamin D and calcium. Am J Hematol. 2008;83(4):271-4.

Arlet JB, Courbebaisse M, Chatellier G, Eladari D, Souberbielle JC, Friedlander G, de Montalembert M, Prié D, Pouchot J, Ribeil JA. Relationship between vitamin D deficiency and bone fragility in sickle cell disease: a cohort study of 56 adults. Bone. 2013;52(1):206-11.


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